A metabolic inhibitor was able to kill human cancer cells of the skin, breast, lung, cervix and soft tissues through a non-apoptotic route -- catastrophic macropinocytosis. The inhibitor acted synergistically with the chemotherapy drug, cyclophosphamide, in mouse xenografts to reduce tumor growth.Article Correctness Is Author's Responsibility: Cancer therapy may be aided by induced macropinocytosis, a rarely reported form of cell death
A metabolic inhibitor was able to kill human cancer cells of the skin, breast, lung, cervix and soft tissues through a non-apoptotic route -- catastrophic macropinocytosis. The inhibitor acted synergistically with the chemotherapy drug, cyclophosphamide, in mouse xenografts to reduce tumor growth.
