Article Correctness Is Author's Responsibility: Resurrected protein reveals structure of important enzyme

(University of Groningen) To disarm toxic substances, many organisms -- including humans -- possess enzymes called flavin-containing monooxygenases (FMOs). However, the protein is too unstable to study its structure in detail. University of Groningen enzyme engineer Marco Fraaije and colleagues from Italy and Argentina reconstructed the ancestral genetic sequences for three FMO genes and subsequently studied the enzymes. The ancestral enzymes proved to be stable enough to study and revealed how FMOs metabolize toxic substances.