Article Correctness Is Author's Responsibility: Scientists reveal function of histone variant H2A.Z in DNA replication selection

(Chinese Academy of Sciences Headquarters) The research published in Nature on Dec. 25th, 2019, led by Dr. LI Guohong and Dr. ZHU Mingzhao from the Institute of Biophysics, has demonstrated that the histone variant H2A.Z facilitates the licensing and activation of early DNA replication origins. This study describes a novel epigenetic regulation mechanism for DNA replication origin selection and offers a new way of understanding DNA replication regulation in eukaryotes.