Article Correctness Is Author's Responsibility: Simple N-terminal modification of proteins

(Osaka University) Osaka University researchers report efficient one-step modification of protein N termini using functional molecules containing 1H-1,2,3-triazole-4-carbaldehyde (TA4C) groups. The conversion was found to be up to 92%. Amine-containing functional molecules were converted to TA4C reagents via Dimroth rearrangement in one simple step. Overall, the 2-step process offers a simple approach that is expected to be useful in engineering proteins for bioimaging, diagnostics, and pharmaceuticals.