Article Correctness Is Author's Responsibility: Tricky reaction sequence gets a major boost from a flow setup and statistics

(Osaka University) Researchers from Osaka University have shown that the enantioselective organocatalyzed Rauhut-Currier and [3+2] annulation sequence in a microflow system can rapidly produce functionalized chiral spirooxindoles (up to 89% yield, 98% ee) within one minute. Although conventional methods for developing a flow synthesis procedure can be costly and labor-intensive, the researchers efficiently optimized multiple parameters by applying a machine learning algorithm. This unique approach may help realize novel synthetic routes in flow systems.