Article Correctness Is Author's Responsibility: Flexible ‘heroes’ save delicate proteins from stress

(PLOS) Protein aggregation and misfolding underpins several neurodegenerative diseases; proteins can also become aggregated or denatured under conditions of stress. A new study published March 12 in the open-access journal PLOS Biology by Kotaro Tsuboyama and Yukihide Tomari of The University of Tokyo, Japan, and colleagues reveals a newly discovered class of proteins in both humans and flies which protect vulnerable proteins from becoming aggregated or denatured in extreme heat and other stresses.