Article Correctness Is Author's Responsibility: Glucagon receptor structures reveal G protein specificity mechanism

(Chinese Academy of Sciences Headquarters) A group led by WU Beili and ZHAO Qiang at the Shanghai Institute of Materia Medica of the Chinese Academy of Sciences (CAS), a group led by SUN Fei at the Institute of Biophysics of CAS, and a group led by Denise Wootten from Monash University, determined two cryo-electron microscopy (cryo-EM) structures of the human glucagon receptor (GCGR) in complex with its cognate agonist glucagon and distinct classes of G proteins, Gs or Gi.